GBMSDG Meeting Archives
November 19, 2008
Michael MacCoss, Ph.D.
Department of Genome Sciences
University of Washington
Targeted and Discovery Based Proteomics:
Complementary Approaches to Differential Proteomics
575 Memeorial Drive, Cambridge
New Objective, Inc.
Special thanks to New Objective for sponsoring this event. It is the active participation of our sponsors that allows us to keep the fees for membership, dinners, drinks, speakers, etc. so low.
About Mike MacCoss
The focus of The MacCoss Group's research is in the development of stable isotope and mass spectrometry based approaches to improve the understanding of biology on a molecular, cellular, and whole organism level. Presently, individuals in the laboratory are working on technology for 1) automating biochemical sample preparation methods for the analysis of protein mixtures; 2) developing in vivo stable isotope methods for studying protein metabolism; 3) increasing the dynamic range of liquid chromatography-mass spectrometry for the analysis of peptides; and 4) developing computational tools for the automated conversion of mass spectrometry data into biologically meaningful results. These technologies are presently being demonstrated in the model organisms C. elegans and S. cerevisiae. Although their current research interests are presently in model systems, their long-term goal is have technologies robust enough to handle the automated high-throughput characterization of human clinical samples.